Effect of Pregabalin on Succinylcholine Induced Fasciculation, Myalgia and Hyperkalemia in Spine Surgery

A randomized control trial was done between January and December of 2018, in the Department Anaesthesia, Analgesia, Palliative & Intensive Care Medicine Dhaka Medical College Hospital, Bangladesh, to evaluate preventive effect pregabalin on succinylcholine induced adverse effects, i.e., fasciculation, myalgia hyperkaliemia spine surgery. Sixty patients elective surgery under general anaesthesia were selected divided into two groups. Pregabalin 150 mg given one group matching placebo another orally with sips water hour before Succinylcholine 1.5 mg/kg after induction agent. Muscle fasciculation observed just administration. Serum potassium measured 5 minutes After completion reversal given. Time first analgesic demand recorded. Injection Morphine 0.15 intramuscular when patient complained about pain. Myalgia (muscle pain not associated surgery) 24 hours total morphine consumption Use reduced severity incidence postoperative myalgia. It also rise serum concentration administration though within normal limit. opioid surgery.
 CBMJ 2023 January: Vol. 12 No. 01 P: 73-80